Florence is an unincorporated community in Paint Township, Madison County, Ohio, United States. It is located along U.S. Route 42 between London and South Charleston.Rand McNally. The Road Atlas '06. Chicago: Rand McNally, 2006, 80.

Florence was never platted; the community simply grew around a station built on the Pennsylvania Railroad.Bryan, Chester E., History of Madison County, Ohio, B.F. Bowen & Company, Inc., Indianapolis, Indiana, 1915, Pg. 182. As of 1915, the community contained one grain elevator, one general store, the railroad station and freight depot, and only a few houses.

References