Adolf Friedrich Johann Butenandt (; 24 March 1903, Lehe near Bremerhaven – 18 January 1995, Munich) was a German biochemist. He was awarded the Nobel Prize in Chemistry in 1939 for his "work on sex hormones." He initially rejected the award in accordance with government policy, but accepted it in 1949 after World War II. He was President of the Max Planck Society from 1960 to 1972. He was also the first, in 1959, to discover the structure of the sex pheromone of silkworms, which he named bombykol.

Education and early life Born in Lehe, near Bremerhaven, he started his studies at Marburg University. For his PhD, he joined the working group of the Nobel laureate Adolf Windaus at the University of Göttingen and he finished his studies with a PhD in chemistry in 1927. His doctoral research was on the chemistry of the insecticidal toxin found in the roots of Derris elliptica which he isolated and characterized. After his Habilitation he became lecturer in Göttingen 1931.

Professional career He became a professor ordinarius at the Technical University of Danzig from 1933 until 1936. In 1933, Butenandt signed the Vow of allegiance of the Professors of the German Universities and High-Schools to Adolf Hitler and the National Socialistic State. In 1936, he applied for the directorship of the Kaiser Wilhelm Institut (later the Max Planck Institute for Biochemistry) in Berlin-Dahlem while also joining the NSDAP on 1 May 1936 (party member No. 3716562). The earlier director of the Kaiser Wilhelm institute was Carl Neuberg, who had been removed for being a Jew. His work on rotenones was considered useful by the Nazi leadership as it could be useful for controlling lice among soldiers in the trenches. As the head of a leading institute, he applied for government funding on concentrated research labeled kriegswichtig (important for the war), some of which focused on military projects like the improvement of oxygen uptake for high-altitude bomber pilots.

Adolf Windaus and Walter Schöller of Schering gave him the advice to work on hormones extracted from ovaries. This research lead to the discovery of estrone and other primary female sex hormones, which were extracted from several thousand liters of urine. While working as professor in Danzig at the Chemisches Institut he was continuing his works over hormones extracting progesterone in 1934 and testosterone a year later, the research results were along with the synthesis of steroids by Leopold Ružička considered significant enough to be awarded later by Nobel Committee in 1939. In 1940 he was involved in research on a hormone treatment to make long submarine voyages more comfortable for submariners in the Kriegsmarine.

Butenand's involvement with the Nazi regime and various themes of research led to criticism after the war, and even after his death the exact nature of his political orientation during the Nazi era has never been fully resolved. When the institute moved to Tübingen in 1945 he became a professor at the University of Tübingen. In 1948, he was considered for the chair for physiological medicine at the University of Basel. He entered in negotiations but eventually was convinced by the chemical industry to stay in Germany. In 1956, when the institute relocated to Martinsried, a suburb of Munich, Butenandt became a professor at the Ludwig-Maximilians-Universität München. He also served as president of the Max Planck Society for the Advancement of Science following Otto Hahn from 1960 to 1972.

Butenandt is credited with the discovery and naming of the silkworm moth pheromone Bombykol in 1959.

Butenandt died in Munich in 1995, at the age of 91. His wife , born in 1906, died in 1995 at 88. They had seven children.

Honours and awards 1939: Nobel Prize in Chemistry (shared with Leopold Ruzicka) for the identification of the sex hormones, oestrogen, progesterone and androsterone 1942: War Merit Cross, Second Class (Germany) 1943: War Merit Cross, First Class (Germany) 1953: Paul Ehrlich and Ludwig Darmstaedter Prize 1959/1964: Knight Commander's Cross and Grand Cross of the Order of Merit of the Federal Republic of Germany 1960: Honorary Citizen of the City of Bremerhaven 1960: President of the Max Planck Society 1961: Wilhelm Normann Medal of the German Society for Fat Research 1962: Bavarian Order of Merit 1962: Pour le Mérite 1964: Austrian Decoration for Science and Art 1967: Cultural Honor Prize of the City of Munich 1969: Commander of the French Legion of Honour 1972: Ordre des Palmes Académiques 1981: Bavarian Maximilian Order for Science and Art 1985: Grand Cross 1st class of the Order of Merit of the Federal Republic of GermanyChronik der Ludwig-Maximilians-Universität München 1984-1986, p.166 1985: Honorary Citizen of the City of Munich 1994: Grand Gold Decoration for Services to the Republic of Austria 1951–1992: 31 participations in the Lindau Nobel Laureate Meetings (record)

Honorary doctorates Butenandt received 14 honorary doctorates,Chronik des Fachbereichs Chemie der Philipps-Universität Marburg including the University of Tübingen (1949), the Ludwig-Maximilians-Universität München (1950), the University of Graz (1957), the University of Leeds (1961), Aristotle University of Thessaloniki (1961), Complutense University of Madrid (1963), the University of Vienna (1965), Saint Louis University (1965), the Humboldt University of Berlin (1966), the University of Cambridge (1966) and Gdańsk University of Technology (1994).

See also Androsterone Conjugated estriol Epiandrosterone Pregnenolone

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External links

1939 Nobel Prize in Chemistry Biography MPG Biography