Nicola Lo Buono (4 June 1933 – 8 September 2009) was an Italian football defender who played as a left-back.

Career Lo Buono began his career with Fortis Trani before moving to Lazio in 1955. He made his debut for the club on 11 March 1956 in a derby against Roma, which Lazio won 1–0. He went on to play 91 league matches for Lazio, and was a member of the side that won the club's first major trophy, the Coppa Italia, in 1958, appearing in eight of the nine matches of that campaign. He moved to Pescara in 1962, where he played for two seasons before retiring.

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