Donough O'Brien may refer to: Donough O'Brien (cricketer) (1879–1953), Welsh-born Irish cricketer Sir Donough O'Brien, 1st Baronet (1642–1717), Irish politician and baronet Donough O'Brien, 16th Baron Inchiquin (1897–1968) Donough O'Brien, 2nd Earl of Thomond (died 1553) Donogh O'Brien, 4th Earl of Thomond (died 1624) Donough O'Brien (died 1582)
See also Donnchad mac Briain (died 1064), 11th-century king of Munster