Velký Karlov is a municipality and village in Znojmo District in the South Moravian Region of the Czech Republic. It has about 400 inhabitants.

Velký Karlov lies approximately east of Znojmo, south-west of Brno, and south-east of Prague.

History Velký Karlov is among the youngest villages in the country. A farm called Velký Karlov was built here in 1950. First houses were built in 1953. The municipality of Velký Karlov was established on 26 November 1971.

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