Second Creek or Secondcreek may refer to:
Second Creek (Adelaide), a tributary of the River Torrens, Adelaide, South Australia Second Creek (Greenbrier River), a stream in West Virginia Second Creek (Mississippi), a tributary of the Homochitto River Second Creek (Pocatalico River), a stream in Kanawha County, West Virginia Second Creek (Uwharrie River tributary), a stream in Randolph County, North Carolina Secondcreek, West Virginia, an unincorporated community