Kosmos 351 ( meaning Cosmos 351), known before launch as DS-P1-Yu No.38, was a Soviet satellite which was launched in 1970 as part of the Dnepropetrovsk Sputnik programme. It was a spacecraft, which was built by the Yuzhnoye Design Bureau, and was used as a radar calibration target for anti-ballistic missile tests.

Launch Kosmos 351 was launched from Site 133/1 at the Plesetsk Cosmodrome, atop a Kosmos-2I 63SM carrier rocket. The launch occurred on 27 June 1970 at 07:39:55 UTC, and resulted in the successful deployment of Kosmos 351 into low Earth orbit. Upon reaching orbit, it was assigned its Kosmos designation, and received the International Designator 1970-051A.

Orbit Kosmos 351 was the thirty-fourth of seventy nine DS-P1-Yu satellites to be launched, and the thirty-first of seventy two to successfully reach orbit. It was operated in an orbit with a perigee of , an apogee of , 70.9 degrees of inclination, and an orbital period of 91.43 minutes. It remained in orbit until it decayed and reentered the atmosphere on 13 October 1970.

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