St. James Hotel may refer to:
St. James Hotel (Jacksonville, Florida), a destroyed hotel, the site of the St. James Building St. James Hotel (Red Wing, Minnesota), listed on the National Register of Historic Places (NRHP) St. James Hotel (Cimarron, New Mexico) St. James Hotel (Philadelphia), listed on the NRHP St. James Hotel (San Diego), part of the Gaslamp Quarter Historic District St James's Hotel and Club, London