Holifield is a surname. Notable people with the surname include:
Chester E. Holifield (1903–1995), United States Representative from California John Holifield (born 1964), American football running back for the West Virginia Mountaineers
See also Mike Hollifield (born 1961), English footballer Holyfield (surname)
See also Ruthie Bolton-Holifield (born 1967), former collegiate, Olympic and professional basketball player