Wain is a surname. Notable people with the surname include:
Bea Wain (1917–2017), American Big Band-era singer David Wain (born 1969), American comedian, writer, actor and director Edward Wain, Robert Towne (born 1934), American screenwriter and director John Wain (1925–1994), English poet, novelist, and critic, associated with the literary group "The Movement" Louis Wain (1860–1939), English artist known for his drawings featuring anthropomorphised large-eyed cats and kittens Louise Wain, English respiratory researcher Richard William Leslie Wain (1896–1917), Welsh recipient of the Victoria Cross William Wain Prior (1876–1946), Commander-in-Chief of the Royal Danish Army, 1939–1941
See also Charles' Wain Burmeister & Wain Waine Pryce