Adapalene/benzoyl peroxide, sold under the brand name Epiduo among others, is a fixed-dose combination medication for the treatment of acne vulgaris. It is a combination of adapalene, a synthetic retinoid; and benzoyl peroxide, an oxidizing agent.
Adapalene/benzoyl peroxide (Epiduo Gel) was approved for medical use in the United States in December 2008. Adapalene/benzoyl peroxide (Epiduo Forte) with a stronger adapalene strength was approved for medical use in the United States in July 2015. Adapalene/benzoyl peroxide (Differin Epiduo Acne Gel) is an over-the-counter version of Epiduo Gel that was approved for medical use in the United States in May 2026.
It is available as a generic medication. In 2023, it was the 319th most commonly prescribed medication in the United States, with more than 200,000 prescriptions.
Medical uses Adapalene/benzoyl peroxide is indicated for the topical treatment of acne vulgaris.
Side effects Commonly reported side effects include the following: Skin redness Scaling Dry skin Contact dermatitis Skin irritation Stinging Burning
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