Headquarters House may refer to:
Hong Kong Headquarters House (Hong Kong), Commander of British Forces Hong Kong
Jamaica Hibbert House, also known as Headquarters House, head office of the Jamaica National Heritage Trust
United States Headquarters House (Fayetteville, Arkansas), listed on the NRHP in Washington County, Arkansas Garden Club of Georgia Museum-Headquarters House, Founder's Memorial Garden, Athens, Georgia, listed on the NRHP in Clarke County, Georgia Headquarters House (Boston), a National Historic Landmark listed on the NRHP