Bartolo or di Bartolo is an Italian and Maltese patronymic surname from the given name Bartolo. Notable people with the surname include:
Andrea di Bartolo (1360–1428), Medieval Italian painter, stained glass designer and illuminator of the Sienese School
Augusto Bartolo (1883–1937), Maltese journalist, politician and judge Benedetto Bartolo (1627–1685), Italian Roman Catholic prelate
Domenico di Bartolo (1400–1445), Early Renaissance Italian painter Erasmo di Bartolo (1606–1656), Italian composer Evarist Bartolo (born 1952), Maltese politician
Giuseppe Di Bartolo (1900–1943), WW II Italian naval officer
Joe Bartolo (born 1969), Australian rugby league footballer Julián Bartolo (born 1996), Argentine footballer Leanne Bartolo (born 1987), Maltese champion bodybuilder Nanni di Bartolo (1450–1450), Florentine Renaissance sculptor
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