Manuel Rodríguez may refer to:
Arts Manuel Rodríguez López (1934–1990), Spanish poet and writer Manuel Rodríguez Lozano (1896–1971), Mexican painter Manuel Rodríguez Objío (1838–1871), Dominican poet and activist Manuel Rodriguez Sr. (1912–2017), aka "Mang Maning", Filipino printmaker
Politics Manuel Rodríguez Cuadros (born 1949), Peruvian politician and diplomat Manuel Rodríguez Erdoíza (1785–1818), Chilean lawyer and guerrilla leader (born 1966), Mexican politician, elected for the 4th federal electoral district of Tabasco Manuel Rodríguez Orellana (born 1948), Puerto Rican legal scholar and political leader Manuel Rodríguez Ramos (1908–????), Puerto Rican writer, professor and politician Manuel Rodríguez Torices (1788–1816), Neogranadine lawyer, journalist, and pro-independence statesman Manuel Rodríguez Valenzuela (1900–1956), Chilean teacher and politician
Science Manuel Rodríguez Gómez (1928–2006), American neurologist
Sports Manuel Rodríguez Arzuaga (1876–1952), Spanish athlete Manolete (Manuel Rodríguez Sánchez, 1917–1947), Spanish bullfighter Manuel Rodríguez (cyclist) (1926–1997), Spanish cyclist Manuel Rodríguez (footballer) (1938–2018), Chilean footballer Manuel Rodríguez Navarro (born 1969), Spanish wheelchair basketball player Manuel Cristian Rodríguez (boxer) (born 1973), Argentine boxer Manuel Rodríguez (first baseman) (born 1985), Panamanian baseball player Manu Rodríguez (basketball) (born 1991), Spanish basketball player Manu Rodríguez (footballer) (born 2005), Spanish footballer Manuel Rodríguez (pitcher) (born 1996), Mexican baseball player Manuel Rodríguez (tennis), Chilean tennis player
Other uses Manuel Rodríguez Patriotic Front, left-wing guerrilla movement in Chile Manuel Rodriguez Island, an island in the Patagonian Archipelago in Magallanes y la Antártica Chilena Region, Chile Manuel Rodríguez (TV series), a 2010 Chilean telenovela based on the life of Manuel Rodríguez Erdoiza