Fort Defiance may refer to:
Canada Fort Defiance (British Columbia), winter quarters for American Captain Robert Gray
United States Fort Defiance, Arizona, an unincorporated community Fort Defiance (California), formerly Roop's Fort, located in Susanville Fort Morris, Georgia, known as Fort Defiance during the War of 1812 Fort Defiance (Illinois), a Civil War post commanded by General Ulysses S. Grant, site of Fort Defiance Park Fort Defiance State Park near Estherville, Iowa Fort Defiance (Maryland), a War of 1812 fort on the Elk River Fort Defiance (Massachusetts), a 19th-century fort in Gloucester Fort Defiance (Brooklyn), a fort in the neighborhood of Red Hook, Brooklyn, New York during the American Revolution Fort Defiance (Lenoir, North Carolina), former plantation home of General William Lenoir Fort Defiance (Ohio), in present-day Defiance, Ohio Gordon Stockade, South Dakota, initially called Fort Defiance Fort Defiance, Tennessee, in Clarksville TN, later renamed Fort Bruce Fort Defiance, briefly the name of the Presidio La Bahía in Goliad, Texas during the Texas Revolution Fort Defiance (Vermont), a fort in Vermont Fort Defiance, Virginia, an unincorporated community Fort Defiance (Wisconsin), a fort during the Black Hawk War
In film Fort Defiance (film), a 1951 Western directed by John Rawlins