Polysphondylium is a genus of cellular slime mold, including the species Polysphondylium pallidum. The genus was circumscribed by German mycologist Julius Oscar Brefeld in 1884.

Species Polysphondylium acuminatum Vadell & Cavender 1998 nom. inv. Polysphondylium aureum Hodgson & Wheller 2001 nom. inv. Polysphondylium fuscans Perrigo & Romeralo 2012 Polysphondylium laterosorum (Cavender 1970) Baldauf, Sheikh & Thulin 2017 Polysphondylium patagonicum Vadell et al. 2011 Polysphondylium violaceum Brefeld 1885

See also Dictyostelium so-called cellular slime mold.

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