GRB or grb may refer to:

Organizations ASX stock code for Gage Roads Brewing Company, an Australian brewery Game Rating Board, former name of the South Korean game rating organization GRB Studios, an American television production company

Science and technology Gamma-ray burst, an astronomical event Granzyme B (GrB), serine protease most commonly found in the granules of NK cells and cytotoxic T cells .grb, the file extension of GRIB files

Transportation Station code for Great Bentley railway station, in Essex, England IATA and FAA codes for Green Bay–Austin Straubel International Airport, in Wisconsin, U.S.

Other uses George R. Brown Convention Center, in Houston, Texas, U.S. Postal code for Għarb, Gozo Island, Malta ISO 639-2 and 639-3 codes for Grebo language, a Kru language spoken in Liberia and the Ivory Coast