Amargosa is the Spanish name of the plant Centaurium erythraea. It may also refer to:
Western United States Animals Amargosa toad Amargosa vole Amargosa Pupfish Station, Nevada
Natural geography Amargosa Desert Amargosa Range Amargosa River Amargosa River Area of Critical Environmental Concern and Wild and Scenic River Amargosa Valley
Populated places and buildings Amargosa Valley, Nevada, a community within the Amargosa Desert/Valley Death Valley Junction, California, formerly named Amargosa Amargosa Opera House and Hotel in Death Valley Junction, California Amargosa, Texas, a census designated place in Texas
Brazil Amargosa, Brazil Roman Catholic Diocese of Amargosa, in Brazil