Coiled coil domain containing 90B, also known as CCDC90B, is a protein encoded by the CCDC90B gene. It is a mitochondrial calcium uniporter binding protein.
Gene
CCDC90B is located on chromosome 11 in humans. It is neighbored by: PCF11, a mammalian pre-mRNA cleavage complex 2 protein ANKRD42, ankyrin repeat protein involved with calcium ion bonding BC070093 DLG2, a member of the membrane-associated guanylate kinase (MAGUK) family
Structure This protein is characterized by the presence of a domain of unknown function, DUF1640. This domain is a characteristic of the entire protein with the exception of the first twenty-three amino acid residues - MNSRQAWRLFLSQGRGDRWVSRP - which are a mitochondrial targeting site and cleaved.
The protein has seven predicted alpha helices, a characteristic of coiled-coil proteins.
Properties
Molecular Weight: 26.72 kDa Isoelectric point: 7.5 Transmembrane Helices: None
Post-translation modifications: Chloroplast transit peptides: None Signal pepties: None C-mannosylation sites: None N-glycosylation sites: None Mitochondrial targeting: Yes Cleaved site: MNSRQAWRLFLSQGRGDRWVSRP
It is predicted to contain at least three specific phosphorylation sites: Protein Kinase C Phosphorylation sites, Casein Kinase II Phosphorylation sites, and cAMP/cGMP Dependent Phosphorylation sites.
References
External links