Humes is a surname. Notable people with the surname include:
Cedric Humes (born 1983), American football running back Edward Humes, American journalist Harold L. Humes (1926–1992), American writer Helen Humes (1913–1981), American jazz and blues singer James C. Humes, American writer Jimmy Humes (born 1942), English footballer Mary-Margaret Humes (born 1954), American actress Marvin Humes (born 1985), British boy band member Rochelle Humes (born 1989), English singer and television presenter Tony Humes (born 1966), English footballer William Y.C. Humes (1830–1883), Confederate general