Matalon is a surname. Notable people with the surname include:
David Matalon (1943–2025), American film producer and studio executive Eli Matalon (1924–1999), Jamaican businessman and politician Martín Matalon (born 1958), Argentinian composer and musician Moshe Matalon (politician) (born 1953), Israeli politician and member of the Knesset for Yisrael Beiteinu Moshe Matalon (engineer) (born 1949), Israeli-American mechanical engineer and mathematician Ronit Matalon (1959–2017), Israeli fiction writer Salomon Matalon, scout leader in Senegal Vivian Matalon (1929–2018), British theatre director Joseph Mayer Matalon (Jamaican businessman and philathropist) (born 1959)
See also Amit, Pollak, Matalon & Co., a law firm in Israel