Greenville Commercial Historic District may refer to:
Greenville Commercial Historic District (Greenville, Kentucky), listed on the NRHP in Muhlenberg County, Kentucky Greenville Commercial Historic District (Greenville, Mississippi), listed on the NRHP in Mississippi Greenville Commercial Historic District (Greenville, North Carolina), listed on the NRHP in Pitt County, North Carolina Greenville South Broadway Commercial District, Greenville, Ohio, listed on the NRHP in Darke County, Ohio Greenville Commercial Historic District (Greenville, Pennsylvania), listed on the NRHP in Mercer County, Pennsylvania