Peyton House or Peyton Building may refer to:
Peyton House (Raymond, Mississippi), listed on the NRHP in Mississippi Peyton-Ellington Building, Charlottesville, Virginia, listed on the NRHP in Virginia Rose Cottage/Peyton House, Charlottesville, Virginia, listed on the NRHP in Virginia Peyton Building and Peyton Annex, Spokane, Washington, listed on the NRHP in Washington