Mazaediothecium is a genus of calicioid lichens in the family Pyrenulaceae. It has four species. The genus was circumscribed by Dutch lichenologist André Aptroot in 1991, with Mazaediothecium rubiginosum assigned as the type species.

Species Mazaediothecium album Mazaediothecium mohamedii – Malaysia Mazaediothecium rubiginosum Mazaediothecium uniseptatum – French Guiana

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