William Caine may refer to:
William Caine (Hong Kong) (1799–1871), Colonial Secretary and acting Governor of Hong Kong William Sproston Caine (1842–1903), British politician and Temperance advocate William Caine (author) (1873–1925), British novelist L. William Caine, college football coach
See also William Cain (disambiguation) William Kane (disambiguation) Caine (surname)