Chesapeake and Ohio Depot may refer to:
Ashland, Kentucky station (Chesapeake and Ohio Railway) Chesapeake and Ohio Depot (Catlettsburg, Kentucky) Charleston, West Virginia (Amtrak station) Charlottesville station (Chesapeake and Ohio Railway) Clifton Forge (Amtrak station), Virginia Culpeper (Amtrak station) Hinton (Amtrak station), West Virginia Lee Hall Depot, Newport News, Virginia Chesapeake and Ohio Depot (Marlinton, West Virginia) Maysville (Amtrak station), Kentucky Chesapeake and Ohio Depot (Mount Sterling, Kentucky) Chesapeake and Ohio Depot (Petoskey, Michigan) Chesapeake and Ohio Depot (Pikeville, Kentucky) Prince (Amtrak station), West Virginia Chesapeake and Ohio Depot (St. Albans, West Virginia) Thurmond (Amtrak station), West Virginia White Sulphur Springs (Amtrak station), West Virginia