Simonetta is an Italian surname and female given. Notable people with the name include:
Given name Simonetta Colonna di Cesarò (1922-2011), Italian duchess and fashion designer Simonetta Moro, Italian fine artist Simonetta Puccini (1929–2017) Simonetta Greggio, Italian novelist who writes in French Simonetta Paloscia, Italian engineer Simonetta Stefanelli (born 1954), Italian actress, born in Rome, Italy Simonetta Vespucci (1453–1476), the wife of the Italian nobleman Marco Vespucci of Florence Simonetta Di Pippo, Italian astrophysicist Simonetta Lein, American model Simonetta Sommaruga, Swiss politician
Surname Family Simonetta di Calabria: Cicco Simonetta (1410–1480), Italian secretary, statesman and cryptographer Giacomo Simonetta (1475–1539), Italian Cardinal and bishop of Pesaro Ludovico Simonetta (1500–1568), Italian Cardinal and bishop of Pesaro Francesco Simonetta (died 1612), Roman Catholic prelate Ada Sacchi Simonetta (1874–1944), Italian librarian Umberto Simonetta (1926–1998), Italian playwright, writer and lyricist
See also 29706 Simonetta, a main-belt asteroid Villa Simonetta, a Renaissance villa located in Milan
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