Francini is a surname. Notable people with the surname include:
Enrique Mario Francini (1916–1978), Argentine tango violinist Giovanni Francini (born 1963), retired Italian footballer Loris Francini (born 1962), San Marinese politician Sebastián Francini (born 1989), Argentine actor Tommaso Francini (1571–1651), Florentine hydraulics engineer and garden designer
See also 42929 Francini, main belt asteroid with an orbital period of 3.7 years