James Gamble may refer to:
James Gamble (industrialist) (1803–1891), U.S.-based Irish soapmaker and industrialist; co-founder of Procter & Gamble Company James Gamble (politician) (1809–1883), U.S. Representative from Pennsylvania James Gamble (telegraph) (1826–1905), Piedmont resident, and builder of the first telegraph in California James Sykes Gamble (1847–1925), English botanist James Fulton Gamble, Northern Irish politician James Gamble (1995–2015), Canadian co-conspirator responsible for the Halifax mass shooting plot James Gamble (pediatrician), America medical researcher