Jamie or James O'Reilly may refer to:
Clergymen James O'Reilly (priest) (1836–1887), American Roman Catholic priest James O'Reilly (bishop) (1855–1934), American Roman Catholic bishop of Fargo, 1909–1934
Public officials James O'Reilly (Canadian politician) (1823–1875), Ontario lawyer and MP James Edwin O'Reilly (1833–1907), Canadian mayor of Hamilton, Ontario James O'Reilly (Irish politician) (1916–1992), Northern Irish nationalist James O'Reilly (judge) (born 1955), Canadian lawyer and Federal judge
Sportsmen Jamie O'Reilly (born 1988), Irish Gaelic footballer James O'Reilly (rugby union) (born 1994), New Zealand hooker
See also James Reilly (disambiguation) James Riley (disambiguation)