Jesse Brown (1944–2002) was the United States Secretary of Veterans Affairs under President Bill Clinton from 1993 to 1997.

Jesse Brown may also refer to: Jesse L. Brown (1926–1950), American naval aviator Jesse Brown (American football) (1902–1987), American football player Jesse Brown (baseball) (1914–1980), American Negro leagues baseball player Jesse Brown (journalist), Canadian journalist Jesse Brown (Indiana politician) (born 1986), American politician