Dominis is a surname. Notable people with the surname include:
John Dominis (1921–2013), American Documentary photographer, war photographer and photojournalist John ʻAimoku Dominis (1883–1917), son of John Owen Dominis John Owen Dominis (1832–1891), American-born statesman John Dominis Holt II (1861–1915), Hawaiian military leader John Dominis Holt IV (1919-1993), Hawaiian writer Marco Antonio de Dominis (1566–1624), Dalmatian ecclesiastic, apostate, and man of science Mary Dominis (1803–1889), American settler of Hawaii
See also Dominis Conspiracy (Hawaii), also known as the Wilcox Rebellion of 1888