Christodoulou () is a surname of Greek origin, the genitive form of the first name Christodoulos (, "Servant of Christ").

Adam Christodoulou (born 1989), British racing driver Anastasios Christodoulou (1932–2002), Cypriot university administrator, Secretary General of the Association of Commonwealth Universities, Foundation Secretary of the British Open University Andreas Christodoulou (footballer, born 1934), Cypriot football player Andreas Christodoulou (footballer, born 1997), Cypriot football player Antreas Christodoulou, or Andreas (born 1995), Cypriot basketball player Apostolos Christodoulou (1856–1917), Greek priest, theologist and bishop Charlie Christodoulou (c.1951–1976), British soldier and mercenary Christodoulos Christodoulou (born 1939), Cypriot economist, lawyer and politician Christos Christodoulou (born 1961), Greek basketball player Daisy Christodoulou, British educationalist, head of education research at the charity Ark Demetrios Christodoulou (born 1951), Greek mathematician and physicist Efthymios Christodoulou (born 1932), Greek economist and banker Evangelia Christodoulou (born 1983), Greek gymnast Fanis Christodoulou (born 1965), Greek basketball player Georgios Christodoulou (born 1965), Cypriot football player Georgios Christodoulou (footballer, born 1967), Greek football player Georgios Christodoulou (footballer, born 1997), Cypriot football player John Christodoulou (born 1965), Cyprus-born British billionaire property developer Jon Christos (born John Christodoulou, 1976), English singer, pianist, arranger, conductor and radio personality Kostas Christodoulou (born 1915), Greek football player and manager Konstantinos Christodoulou (born 1986), Greek track cyclist Louis Christodoulou (born 1967), Australian soccer player Maria Christodoulou (born 1980), Greek synchronized swimmer Marios Christodoulou (born 1974), Cypriot football player Monika Christodoulou (born 1985), Greek singer-songwriter Nico Christodoulou (born 2005), Canadian racing driver Nikolaos Christodoulou (1863–c.1924), Greek army general Nikos Christodoulou (born 1959), Greek conductor and composer Pambos Christodoulou (born 1967), Cypriot football player and manager Petros Christodoulou (born 1960), Greek economist and banker Riki Christodoulou (born 1988), British racing driver Stanley Christodoulou (born 1946), South African boxing referee Stavros Christodoulou (born 1963), Cypriot writer Stella Christodoulou (born 1991), Greek volleyball player Theodoros Christodoulou (born 1977), Cypriot alpine skier

See also Charlie Crist (born 1956), Governor of Florida, whose surname is derived from 'Christodoulou'