Busuttil is a Maltese surname, probably a derivative of the medieval Maltese surname Busittin – meaning master of 60 men. Notable people with the surname include:
Albert Busuttil (1891–1956), Maltese philosopher Carmel Busuttil (born 1964), Maltese footballer George Busuttil (born 1939), Maltese diplomat Jeanne-Marie Busuttil (born 1976), French golfer Simon Busuttil (born 1969), Maltese politician Vincenzo Busuttil (1860–1922), Maltese poet Julia Busuttil (born 1988), Maltese-Australian cookbook author
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