Grizzard is a surname. Notable people with the surname include:
Ephraim Grizzard (died 1892), African-American lynching victim Frank E. Grizzard, Jr. (born 1954), American historian, writer, and documentary editor George Grizzard (1928–2007), American actor Herman Grizzard (died 1971), American radio disc jockey Lewis Grizzard (1946–1994), American writer and humorist Rod Grizzard (born 1980), American basketball player