Fixed drug reactions are common and so named because they recur at the same site with each exposure to a particular medication. Medications inducing fixed drug eruptions are usually those taken intermittently.
Signs and symptoms A painful and itchy reddish/purple patch of skin that occurs in the same location with repeated exposures to the causative drug is the classic presentation of a fixed drug reaction. The lips, genitals, and hands are often involved.
Cause Medications that are commonly implicated as a cause of fixed drug eruptions include the following: Cetirizine Ciprofloxacin Clarithromycin Cotrimoxazole Doxycycline Fluconazole NSAIDs (e.g., ibuprofen, etoricoxib, naproxen) Phenytoin Pseudoephedrine Trimethoprim
See also Drug eruption List of cutaneous conditions List of human leukocyte antigen alleles associated with cutaneous conditions Stevens–Johnson syndrome
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