Anne O'Brien may refer to:

Anne O'Brien, 2nd Countess of Orkney (died 1756), Scottish noblewoman Anne O'Brien (athlete) (1911–2007), American track and field athlete Anne O'Brien (footballer), Irish footballer Anne Philomena O'Brien, Australian historian Ann O'Brien (runner), Irish runner Ann O'Brien, comic book superheroine See also Anne Rice (Howard Allen Frances O'Brien, 1941–2021), American author