Samuel Patterson or Sam Patterson may refer to:
Samuel F. Patterson (1799–1874), North Carolina politician, planter, and businessman Samuel James Patterson (born 1948), Northern Irish mathematician Samuel L. Patterson (1850–1908), North Carolina politician and farmer Sam Patterson (fl. 1917), American football coach Sam Patterson (footballer) (born 1993), English footballer
See also Samuel Patterson House, in Derry Township, Westmoreland County, Pennsylvania, U.S.