Andre Agassi defeated Stefan Edberg in the final, 6–1, 6–4, 0–6, 6–2 to win the men's singles tennis title at the 1990 Miami Open.
Ivan Lendl was the defending champion, but lost in the fourth round to Emilio Sánchez.
Seeds All seeds received a bye to the second round.
Main draw
Finals
Top half
Section 1
Section 2
Section 3
Section 4
Bottom half
Section 5
Section 6
Section 7
Section 8
References 1990 Lipton International Players Championships Singles Draw