Langone is an Italian surname. Notable people with the surname include:
Aboubacar Langone (born 2000), Italian footballer Clementina Poto Langone (1896–1964), Italian-American community activist Frederick C. Langone (1921–2001), American politician Joseph A. Langone Jr. (1896–1960), American politician Ken Langone (born 1935), American venture capitalist Michael Langone (born 1947), American counseling psychologist Oscar Langone (born 1953), Argentine-Australian footballer Stefano Langone (born 1989), American singer
See also NYU Langone Health, academic medical center Langone Park, park in Boston, Massachusetts