Ophis is Greek for "serpent", and may refer to: The constellation Serpens Ophis (Pontus), a town of ancient Pontus, now in Turkey Ophis (river), a river of ancient Anatolia Serpent (Bible), a figure in the Hebrew bible SS Ophis, a cargo ship built in 1919 and which was sunk in 1942 when named Empire Antelope Ophis (High School DxD), a character in the light novel series High School DxD

See also Apep