Frank Hughes may refer to:
Frank Hughes (artist) (1905–1987), British artist Frank Hughes (runner) (1908–?), Canadian long-distance runner Frank Hughes (footballer, born 1894) (1894–1978), nicknamed Checker, Australian rules footballer Frank Hughes (footballer, born 1909) (1909–2002), Australian rules footballer Frank Hughes (ice hockey) (born 1949), Canadian ice hockey player Frank Hughes (sport shooter) (1881–1942), American sport shooter Frank Hughes Jr. (1921–2008), Australian rules footballer Frank E. Hughes (1893–1947), American set decorator Frank John Hughes (born 1967), American actor Frank Joseph Hughes (1883–1967), Canadian lawyer Frank Hughes College, Clifton, Tennessee
See also Francis Hughes (1956–1981), volunteer in the IRA who died in the 1981 Irish hunger strike Francis Wade Hughes (1817–1885), Pennsylvania lawyer and politician