Prime Evil may refer to:

Prime Evil (album), by Venom, 1989 Prime Evil (EP), by Raymond Watts, 1997 Prime Evil (anthology), a 1988 anthology of horror short stories Prime Evil (Buffy novel), a 2000 Buffy the Vampire Slayer novel Prime Evil, the primary villain in the animated series Ghostbusters Eugene de Kock (born 1949), nicknamed Prime Evil, South African former police colonel and assassin

See also Primeval (disambiguation)