David Weiss may refer to:
Music David Weiss (musician) (born 1964), jazz trumpeter, composer, and arranger David Was (born 1952), stage name of David Weiss, American musician and producer
Science and academia David Weiss (physicist), American physicist David Solomon Weiss (born 1953), Canadian organizational psychologist and business strategist David Weiss Halivni (1927–2022), Israeli-American scholar and professor of Jewish studies and the Talmud
Writers David Weiss (novelist) (1909–2002), American author David N. Weiss, American screenwriter, executive in the Writers Guild of America David S. Weiss (fl. 1995), American comedy writer, radio sidekick for Dennis Miller
Other David Weiss (1946–2012), of duo Peter Fischli & David Weiss, Swiss multi-media artist David C. Weiss (born 1956), United States Attorney for the District of Delaware David Weiss (footballer) (born 2007), Finnish footballer