John Wilkes (1725–1797) was an English radical journalist and politician.
John Wilkes may also refer to: John Wilkes (banker), founder of the First National Bank of Charlotte John Wilkes (printer) (1750–1810), English printer, bookseller and stationer John Wilkes (archaeologist) (born 1936), British archaeologist and academic John E. Wilkes (1895–1957), vice admiral, U.S. Navy John Vaughan Wilkes (1902–1986), English educationalist and Anglican priest John Wilkes (train), the name given to a passenger train of the Lehigh Valley Railroad
See also John Wilkes Booth (1838–1865), American actor, known for assassinating president Abraham Lincoln at Ford's Theatre in 1865 John Wilks (1776–1854), English Whig Party politician