The Territorial Prelature of Santo Cristo de Esquípulas () was a Roman Catholic territorial prelature located in the city of Esquipulas, Chiquimula in Guatemala. On June 24, 1986 it became part of the Diocese of Zacapa y Santo Cristo de Esquipulas.
History September 16, 1956: Established as Territorial Prelature of Santo Cristo de Esquípulas from the Roman Catholic Diocese of Zacapa June 24, 1986: Suppressed and became part of the Diocese of Zacapa y Santo Cristo de Esquipulas
Special churches Minor Basilicas: Basílica del Cristo Negro de Esquipulas, Esquipulas, Chiquimula
Leadership Prelates of Santo Cristo de Esquípulas (Roman rite) Archbishop Mariano Rossell y Arellano (1956) Bishop Costantino Cristiano Luna Pianegonda, O.F.M. (September 16, 1956 – February 16, 1980)
References GCatholic.org Prelature website (Spanish)