Sempé is a French surname. Notable people with the surname include:
Carlota Sempé (born 1942), Argentine archaeologist Gabriel Sempé (1901–1990), French athlete Inga Sempé (born 1968), French designer and constructor of technical items Jean-Jacques Sempé (1932–2022), French cartoonist Skip Sempé (born 1958), American harpsichordist and conductor
Places Sempe, Lesotho