4E or 4e or 4-E may refer to:
People Forrest J Ackerman or 4e (1916–2008), American science fiction fan and collector
Art, entertainment, and media 4E TV, a Greek TV station based in Thessaloniki GURPS 4e Basic Set, an edition of the GURPS role-playing system NJS4E (New Jack Swing For Ever), a company, network, events, and on-air programming honoring new jack swing The 4th edition of Dungeons & Dragons, abbreviated as 4E 4E, the production code for the 1975 Doctor Who serial Genesis of the Daleks
Other uses 4E cognition, view of cognition of the extended mind thesis 4th meridian east, a longitude coordinate Het 4e Gymnasium, a public gymnasium in the Netherlands Potez 4E, a French air-cooled flat-four piston engine of the 1960s Sedan 4E, a variation of the McCulloch MC-4 helicopter
See also Douglas DC-4E, an American experimental airliner developed before World War II E4 (disambiguation) eIF4E, Eukaryotic translation initiation factor 4E, a protein