Arkham is a fictional city in Massachusetts, created by H. P. Lovecraft.

Arkham may also refer to:

Arkham Asylum, a fictional psychiatric hospital in the DC Comics Universe Amadeus Arkham, the fictional founder of Arkham Asylum Jeremiah Arkham, the fictional current head of Arkham Asylum Arkham (Devil May Cry), one of the main antagonists in the Devil May Cry video game series Batman: Arkham, a series of video games set in the Batman universe "Arkham" (Gotham), a television episode Arkham Intelligence, a public blockchain and cryptocurrency data application