Pfitzner is a German surname. Notable people with the surname include:
Alexander Pfitzner (1880–1910), Hungarian-American engineer, designer and aviation pioneer Bernice Pfitzner (born 1938), Australian politician Gavin Pfitzner (born 1966), Australian tennis player Hans Pfitzner (1869–1949), German composer Josef Pfitzner (1901–1945), German politician Marc Pfitzner (born 1984), German footballer